Risk of acute kidney injury and mortality in patients vaccinated for Covid-19

More kidney scares, fewer deaths after vax? Comment section goes nuclear

TLDR: A massive study found vaccinated people had more acute kidney issues but lower death rates after a year. Comments split between “this sounds scary” and “immune side effects are rare and expected,” with big debates over causation and jokes about choosing kidneys over the Grim Reaper.

A huge new study out of Taiwan using the TriNetX database looked at 1.45 million vaccinated people versus 1.45 million unvaccinated, and the headline everyone’s fighting over is this: the vaccinated group had more acute kidney injury (sudden kidney trouble) and more dialysis, but lower death rates after a year. Cue the internet meltdown. One camp is shouting, “So… higher kidney risk but you’re more likely to stay alive? What does that even mean for me?” echoing benterix’s practical worry. Another camp, like spwa4, says this isn’t shocking because vaccines stimulate the immune system—“that’s their job”—and rare organ flare-ups happen with lots of immune triggers, even a stubbed toe. Skeptics are tossing “correlation ≠ causation” around, arguing sicker or older people might have been more likely to get vaccinated, while pro-vax commenters counter with the lower mortality as the mic drop. The memes are brutal: “Choose your fighter: kidneys vs Grim Reaper,” and “New side quest unlocked: Visit a nephrologist.” Amid the drama, calmer voices remind everyone this is an association study, not proof of cause, and urge reading the paper before panic-sharing. Here’s the source if you dare: Int J Med Sci.

Key Points

  • Retrospective cohort study using TriNetX compared 1,454,791 vaccinated and 1,454,791 matched unvaccinated patients.
  • Vaccinated group showed higher incidence of AKI (HR 1.20; 95% CI 1.18–1.23) and dialysis (HR 1.84; 95% CI 1.68–2.01) over one year.
  • Observed events: 15,809 AKI and 1,513 dialysis in vaccinated vs 11,801 AKI and 697 dialysis in unvaccinated.
  • Vaccination was associated with lower mortality (HR 0.88; 95% CI 0.85–0.91) compared to unvaccinated.
  • Cumulative probability of AKI and dialysis was significantly higher in the vaccinated group.

Hottest takes

“OK, so in spite of higher ratio of incidents in the vaccinated group the overall mortality was lower. The question is, what are the consequences of that for an average person” — benterix
“Yes, triggering the immune system will in very rare cases cause liver, kidney failure and sometimes vascular problems. Yes, vaccines trigger the immune system. That’s the point of them” — spwa4
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