Heritability of intrinsic human life span is about 50%

Is half your lifespan in your DNA? Commenters split between 'born this way' and 'hit the gym'

TLDR: A Science study says about half of how long you live is in your genes once accidents and infections are excluded. Commenters battle over twin-study math, shared environments, and lifestyle, with some quanting ~7 years you can still control—raising big questions for medicine and personal choices.

A new study in Science just dropped a bomb: once you remove “extrinsic” deaths like accidents and infections, human lifespan looks about 50% genetic. The researchers mined century-old Scandinavian twin records—including twins raised together and apart—and say past low estimates were muddied by random bad luck. Cue the internet cage match: half the crowd cheers that longevity finally joins other traits in the “yep, genes matter” club, while the rest declares, “not so fast—your habits still count.” Numbers nerd Enginerrrd even ran back-of-the-envelope math: life expectancy varies roughly 12 to 15 years, and lifestyle might still swing 6 to 7.5 years. Translation: you can’t out-run your DNA, but you can jog around it.

Then the skepticism brigade arrives. emp17344 argues twin-based heritability is inflated and drops a spicy link. moi2388 worries the study overestimates genetics by lumping in shared childhood environments. Meanwhile logicallee tosses a tangential brain paper for flavor, and the thread devolves into meme territory: “eat your veggies, but also pick better parents.” Anecdotes roll in, like JoeAltmaier’s family roulette—grandparents at 97 and 81—fueling the “longevity lottery” joke. Verdict from the comments: genes set the table, but you still choose some of the menu. For now, debate rages.

Key Points

  • The study corrects life span heritability estimates by accounting for extrinsic mortality (accidents, infections, violence).
  • Analyses use more than a century of data from three Scandinavian twin cohorts, including twins raised together and apart.
  • Intrinsic human life span heritability is found to be above 50% after correcting for extrinsic mortality.
  • Previous estimates (twin 20–25%; pedigree 6–16%) are likely underestimated due to confounding by extrinsic deaths.
  • The corrected heritability aligns with other complex human traits and with life-span heritability observed in crossbred wild mice (38–55%).

Hottest takes

"maybe account for half of that, so like 6-7.5 years of variance" — Enginerrrd
"heritability estimates derived from twin studies are themselves dramatically inflated" — emp17344
"wouldn’t this lead to overestimation of heritability due to shared environment?" — moi2388
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